Article 7122

Title of the article

The effect of tibia perforation on the strength of humerus in juvenile rats with streptozotocin-induced diabetes 

Authors

Aleksandr V. Torba, Candidate of medical sciences, associate professor, head of the sub-department of hospital surgery, urology and oncology, Saint Luka Lugansk State Medical University (1g quarter of the 50th anniversary of the Defense of Lugansk, Lugansk, 91045, Lugansk People’s Republic), E-mail: alexandr_v_torba@mail.ru 

Abstract

Background. The purpose of the research is to investigate the dynamic changes of humerus strength in juvenile streptozotocin-induced diabetic rats after surgical perforation of the tibia. Materials and methods. Diabetes (35 animals with body weight of 135-150 g at the age of 3 months) was induced by a single intraperitoneal injection of streptozotocin in dosage of 55 mg per kg of body weight. Surgical perforation of the tibia was modeled as 2 mm through opening in the proximal metadiaphysis (35 animals). Another group comprised 35 animals with both perforation and diabetes. 35 intact animals comprised the control group. Strength testing was performed by means of three-point bending loading technique at a loading speed of 10 μm per minute. Strength features were calculated from resulting displacement curves. Results. Surgical perforation of the tibia results in decrease of strength of the humerus; manifestations peak was observed on the 30th day after intervention. By the 30th day elasticity modulus, ultimate strength, and fracture energy were lower than those of the controls by 10.83 %, 13.47 %, and 13.60 % (hereinafter, all the given numerical differences are statistically significant, p≤0.05). In streptozotocin-induced diabetes humerus strength features depend on duration of the experiment. By the 90th day ultimate strength, elasticity modulus, and fracture energy were lower than those of the controls by 11.97 %, 4.53 %, and 10.59 %. Fracture of the tibia in streptozotocin-induced diabetes leads to aggravation of strength disorders beginning from the 7th day of observation. By the 90th day elasticity modulus, ultimate strength, and fracture energy decreased by 10.74 %, 9.08 %, and 8.22 % respectively (in comparison with non-diabetic animals with fracture of the tibia). Conclusions. Surgical perforation of the tibia in streptozotocin-induced diabetic juvenile rats leads to aggravation of humerus strength disorders from the 7th day after intervention. 

Key words

rats, streptozotocin-induced diabetes, bone surgical perforation, strength 

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For citation:

Torba A.V. The effect of tibia perforation on the strength of humerus in juvenile rats with streptozotocin-induced diabetes. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Meditsinskie nauki = University proceedings. Volga region. Medical sciences. 2022;(1):71–78. (In Russ.). doi:10.21685/2072-3032-2022-1-7

 

Дата создания: 06.04.2022 14:21
Дата обновления: 06.04.2022 15:09